Puniyani has been spreading the message of peace and amity through lectures, publications, workshops and meetings and by travelling extensively to different parts of the country disseminating messages of secularism, pluralism and communal harmony, a former professor of biomedical engineering and former senior medical officer affiliated with the Indian Institute of Technology Bombay. He began his medical career in 1973 and served IIT in various capacities for 27 years, beginning 1977. In December 2004, he took voluntary retirement to work full-time for communal harmony in India. He is involved with human rights activities, communal harmony and initiatives to oppose the rising tide of fundamentalism in India. He is associated with the organisations All-India Secular Forum, Center for Study of Society and Secularism and ANHAD. In 2006, he was awarded the Indira Gandhi Award for National Integration.